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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   FGF1 Antibody (clone 2E12)   

FGF1 Antibody (clone 2E12)

Mouse Monoclonal Antibody

  • WB - FGF1 Antibody (clone 2E12) ALS14049
    Western blot of FGF1 expression in transfected 293T cell line by FGF1 monoclonal antibody clone...
  • IF - FGF1 Antibody (clone 2E12) ALS14049
    Immunofluorescence of monoclonal antibody to FGF1 on HeLa cell. [antibody concentration 10 ug/ml].
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P05230
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2E12
Calculated MW 17kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml),
Additional Information
Gene ID 2246
Other Names Fibroblast growth factor 1, FGF-1, Acidic fibroblast growth factor, aFGF, Endothelial cell growth factor, ECGF, Heparin-binding growth factor 1, HBGF-1, FGF1, FGFA
Target/Specificity Human FGF1
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsFGF1 Antibody (clone 2E12) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FGF1
Synonyms FGFA
Function Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
Cellular Location Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59.
Tissue Location Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle
Research Areas
Citations (0)

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Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.


Jaye M.,et al.Science 233:541-545(1986).
Mergia A.,et al.Biochem. Biophys. Res. Commun. 164:1121-1129(1989).
Wang W.P.,et al.Mol. Cell. Biol. 9:2387-2395(1989).
Chiu I.M.,et al.Oncogene 5:755-762(1990).
Wang W.P.,et al.Oncogene 6:1521-1529(1991).

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$ 450.00
Cat# ALS14049
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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