|Application ||WB, IHC-P, IF, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||IF (30 µg/ml), IHC-P (10 µg/ml), WB (1:500-1:1000)|
|Other Names||Neuroendocrine convertase 1, NEC 1, 188.8.131.52, Prohormone convertase 1, Proprotein convertase 1, PC1, PCSK1, NEC1|
|Reconstitution & Storage||Store at -20°C|
|Precautions||PCSK1 Antibody (clone 3D2) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules|
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Provided below are standard protocols that you may find useful for product applications.
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.
Creemers J.W.M.,et al.FEBS Lett. 300:82-88(1992).
Seidah N.G.,et al.DNA Cell Biol. 11:283-289(1992).
Ohagi S.,et al.Diabetes 45:897-901(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
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