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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GGT1 / GGT Antibody (clone 1F9)   

GGT1 / GGT Antibody (clone 1F9)

Mouse Monoclonal Antibody

     
  • WB - GGT1 / GGT Antibody (clone 1F9) ALS14058
    GGT1 monoclonal antibody clone 1F9 Western blot of GGT1 expression in NIH/3T3.
  • IHC - GGT1 / GGT Antibody (clone 1F9) ALS14058
    Anti-GGT1 / GGT antibody IHC of human kidney, tubules.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, IP
Primary Accession P19440
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Clone Names 1F9
Calculated MW 61kDa
Dilution IHC-P (5 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 2678
Other Names Gamma-glutamyltranspeptidase 1, GGT 1, 2.3.2.2, Gamma-glutamyltransferase 1, Glutathione hydrolase 1, 3.4.19.13, Leukotriene-C4 hydrolase, 3.4.19.14, CD224, Gamma-glutamyltranspeptidase 1 heavy chain, Gamma-glutamyltranspeptidase 1 light chain, GGT1, GGT
Target/Specificity Human GGT1
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsGGT1 / GGT Antibody (clone 1F9) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GGT1
Synonyms GGT
Function Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide, cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Isoform 3 seems to be inactive.
Cellular Location Cell membrane; Single-pass type II membrane protein
Tissue Location Detected in fetal and adult kidney and liver, adult pancreas, stomach, intestine, placenta and lung. Isoform 3 is lung-specific. There are several other tissue-specific forms that arise from alternative promoter usage but that produce the same protein
Research Areas
Citations (0)

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Background

Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide, cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Isoform 3 seems to be inactive.

References

Rajpert-De Meyts E.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:8840-8844(1988).
Sakamuro D.,et al.Gene 73:1-9(1988).
Pitot H.C.,et al.Toxicol. Appl. Pharmacol. 97:23-34(1989).
Goodspeed D.C.,et al.Gene 76:1-9(1989).
Pawlak A.,et al.J. Biol. Chem. 265:3256-3262(1990).

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$ 450.00
Cat# ALS14058
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