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HTT / Huntingtin Antibody (clone 3F1)

Mouse Monoclonal Antibody

     
  • WB - HTT / Huntingtin Antibody (clone 3F1) ALS14060
    HD monoclonal antibody clone 3F1. Western blot of HD expression in U-2 OS.
    detail
  • IHC - HTT / Huntingtin Antibody (clone 3F1) ALS14060
    Anti-HTT / Huntingtin antibody IHC of human brain, cerebellum.
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P42858
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3F1
Calculated MW 348kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 3064
Other Names Huntingtin, Huntington disease protein, HD protein, HTT, HD, IT15
Target/Specificity Human Huntingtin
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsHTT / Huntingtin Antibody (clone 3F1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HTT
Synonyms HD, IT15
Function [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.
Cellular Location [Huntingtin]: Cytoplasm. Nucleus. Early endosome. Note=The mutant Huntingtin protein colocalizes with AKAP8L in the nuclear matrix of Huntington disease neurons. Shuttles between cytoplasm and nucleus in a Ran GTPase- independent manner (PubMed:15654337). Recruits onto early endosomes in a Rab5- and HAP40-dependent fashion (PubMed:16476778)
Tissue Location Expressed in the brain cortex (at protein level). Widely expressed with the highest level of expression in the brain (nerve fibers, varicosities, and nerve endings). In the brain, the regions where it can be mainly found are the cerebellar cortex, the neocortex, the striatum, and the hippocampal formation
Research Areas
Citations (0)
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Background

May play a role in microtubule-mediated transport or vesicle function.

References

Macdonald M.,et al.Cell 72:971-983(1993).
Matsuyama N.,et al.Genomics 69:72-85(2000).
Hillier L.W.,et al.Nature 434:724-731(2005).
Ambrose C.M.,et al.Somat. Cell Mol. Genet. 20:27-38(1994).
Lin B.,et al.Genomics 25:707-715(1995).

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Discontinued
Cat# ALS14060
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