HSET / KIFC1 Antibody (clone 2B9)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | Q9BW19 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 2B9 |
Calculated MW | 74kDa |
Dilution | IF (10 µg/ml), IHC-P (5 µg/ml), |
Gene ID | 3833 |
---|---|
Other Names | Kinesin-like protein KIFC1, Kinesin-like protein 2, Kinesin-related protein HSET, KIFC1, HSET, KNSL2 |
Target/Specificity | Human KIFC1 |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | HSET / KIFC1 Antibody (clone 2B9) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KIFC1 |
---|---|
Synonyms | HSET, KNSL2 |
Function | Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9QWT9}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9QWT9}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9QWT9}. Early endosome {ECO:0000250|UniProtKB:Q9QWT9}. Note=Associated with nucleus during interphase, centrosomes in early and spindle in later mitosis {ECO:0000250|UniProtKB:Q9QWT9} |
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Background
Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles.
References
Janitz K.,et al.Immunogenetics 49:644-652(1999).
Mungall A.J.,et al.Nature 425:805-811(2003).
Ando A.,et al.Immunogenetics 39:194-200(1994).
Zhu C.,et al.Mol. Biol. Cell 16:3187-3199(2005).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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