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KLF11 Antibody (clone 10D8)

Mouse Monoclonal Antibody

     
  • WB - KLF11 Antibody (clone 10D8) ALS14070
    KLF11 monoclonal antibody, clone 10D8 Western blot of KLF11 expression in NIH/3T3.
  • IF - KLF11 Antibody (clone 10D8) ALS14070
    Immunofluorescence of monoclonal antibody to KLF11 on NIH/3T3 cell.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession O14901
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Clone Names 10D8
Calculated MW 55kDa
Dilution IF (10 µg/ml), IHC-P (10 µg/ml),
Additional Information
Gene ID 8462
Other Names Krueppel-like factor 11, Transforming growth factor-beta-inducible early growth response protein 2, TGFB-inducible early growth response protein 2, TIEG-2, KLF11, FKLF, TIEG2
Target/Specificity Human KLF11
Reconstitution & Storage Store at -20°C, avoid freeze thaw cycles.
PrecautionsKLF11 Antibody (clone 10D8) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLF11
Synonyms FKLF, TIEG2
Function Transcription factor (PubMed:9748269, PubMed:10207080). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity).
Cellular Location Nucleus.
Tissue Location Ubiquitous. Higher expression in erythroid cells.
Research Areas
Citations (0)

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Background

Transcription factor. Activates the epsilon- and gamma- globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.

References

Cook T.,et al.J. Biol. Chem. 273:25929-25936(1998).
Asano H.,et al.Mol. Cell. Biol. 19:3571-3579(1999).
Scohy S.,et al.Genomics 70:93-101(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).

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$ 450.00
Cat# ALS14070
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