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STAG1 / SA1 Antibody (clone 2E9)

Mouse Monoclonal Antibody

     
  • WB - STAG1 / SA1 Antibody (clone 2E9) ALS14079
    Western blot of STAG1 expression in HeLa cells with STAG1 monoclonal antibody, clone 2E9.
  • IF - STAG1 / SA1 Antibody (clone 2E9) ALS14079
    Immunofluorescence of monoclonal antibody to STAG1 on HeLa cell. [antibody concentration 10 ug/ml]
  • IHC - STAG1 / SA1 Antibody (clone 2E9) ALS14079
    Anti-STAG1 antibody IHC of human breast.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q8WVM7
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2E9
Calculated MW 144kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 10274
Other Names Cohesin subunit SA-1, SCC3 homolog 1, Stromal antigen 1, STAG1, SA1
Target/Specificity Human Stromal Antigen 1
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsSTAG1 / SA1 Antibody (clone 2E9) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STAG1
Synonyms SA1
Function Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
Cellular Location Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation
Research Areas
Citations (0)

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Background

Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.

References

Carramolino L.,et al.Gene 195:151-159(1997).
Carramolino L.,et al.Gene 206:283-286(1998).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Sumara I.,et al.J. Cell Biol. 151:749-762(2000).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).

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$ 450.00
Cat# ALS14079
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