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STAG1 / SA1 Antibody (clone 2E9)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q8WVM7 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 2E9 |
| Calculated MW | 144kDa |
| Dilution | IF (10 µg/ml), IHC-P (5 µg/ml), WB (1:500-1:1000) |
| Gene ID | 10274 |
|---|---|
| Other Names | Cohesin subunit SA-1, SCC3 homolog 1, Stromal antigen 1, STAG1, SA1 |
| Target/Specificity | Human Stromal Antigen 1 |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | STAG1 / SA1 Antibody (clone 2E9) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STAG1 |
|---|---|
| Synonyms | SA1, SCC3 {ECO:0000303|PubMed:22628566} |
| Function | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. |
| Cellular Location | Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation |
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
References
Carramolino L.,et al.Gene 195:151-159(1997).
Carramolino L.,et al.Gene 206:283-286(1998).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Sumara I.,et al.J. Cell Biol. 151:749-762(2000).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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