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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   STAG2 Antibody (clone 3C6)   

STAG2 Antibody (clone 3C6)

Mouse Monoclonal Antibody

     
  • WB - STAG2 Antibody (clone 3C6) ALS14080
    Western blot of STAG2 expression in HeLa nuclear extract with STAG2 monoclonal antibody, clone 3C6.
  • WB - STAG2 Antibody (clone 3C6) ALS14080
    Western blot of STAG2 expression in NIH/3T3 cells with STAG2 monoclonal antibody, clone 3C6.
  • IF - STAG2 Antibody (clone 3C6) ALS14080
    Immunofluorescence of monoclonal antibody to STAG2 on HeLa cell. [antibody concentration 10 ug/ml]
  • IHC - STAG2 Antibody (clone 3C6) ALS14080
    Anti-STAG2 antibody IHC of human breast.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q8N3U4
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Clone Names 3C6
Calculated MW 141kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml),
Additional Information
Gene ID 10735
Other Names Cohesin subunit SA-2, SCC3 homolog 2, Stromal antigen 2, STAG2, SA2
Target/Specificity Human Nuclear Protein SA-2
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsSTAG2 Antibody (clone 3C6) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STAG2
Synonyms SA2
Function Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
Cellular Location Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex
Research Areas
Citations (0)

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Background

Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.

References

Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Ross M.T.,et al.Nature 434:325-337(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Carramolino L.,et al.Gene 195:151-159(1997).
Carramolino L.,et al.Gene 206:283-286(1998).

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$ 450.00
Cat# ALS14080
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