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MECP2 Antibody (clone 4B6)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P51608 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 4B6 |
| Calculated MW | 52kDa |
| Dilution | IHC-P (5 µg/ml), WB (1:500-1:1000), |
| Gene ID | 4204 |
|---|---|
| Other Names | Methyl-CpG-binding protein 2, MeCp-2 protein, MeCp2, MECP2 |
| Target/Specificity | Human MeCP2 |
| Reconstitution & Storage | For long term, store at -20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | MECP2 Antibody (clone 4B6) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MECP2 |
|---|---|
| Function | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)- containing DNA, with a preference for 5-methylcytosine (5mC). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9Z2D6}. Note=Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci. |
| Tissue Location | Present in all adult somatic tissues tested. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC) (By similarity).
References
Kudo S.,et al.Mol. Cell. Biol. 18:5492-5499(1998).
Vilain A.,et al.Cytogenet. Cell Genet. 74:293-294(1996).
Coy J.F.,et al.Hum. Mol. Genet. 8:1253-1262(1999).
Reichwald K.,et al.Mamm. Genome 11:182-190(2000).
Mnatzakanian G.N.,et al.Nat. Genet. 36:339-341(2004).
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