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MECP2 Antibody (clone 4B6)

Mouse Monoclonal Antibody

     
  • WB - MECP2 Antibody (clone 4B6) ALS14094
    MECP2 monoclonal antibody clone 4B6. Western blot of MECP2 expression in rat muscle.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P51608
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Clone Names 4B6
Calculated MW 52kDa
Dilution IHC-P (5 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 4204
Other Names Methyl-CpG-binding protein 2, MeCp-2 protein, MeCp2, MECP2
Target/Specificity Human MeCP2
Reconstitution & Storage For long term, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsMECP2 Antibody (clone 4B6) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MECP2
Function Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
Cellular Location Nucleus. Note=Colocalized with methyl-CpG in the genome
Tissue Location Present in all adult somatic tissues tested.
Research Areas
Citations (0)

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Background

Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC) (By similarity).

References

Kudo S.,et al.Mol. Cell. Biol. 18:5492-5499(1998).
Vilain A.,et al.Cytogenet. Cell Genet. 74:293-294(1996).
Coy J.F.,et al.Hum. Mol. Genet. 8:1253-1262(1999).
Reichwald K.,et al.Mamm. Genome 11:182-190(2000).
Mnatzakanian G.N.,et al.Nat. Genet. 36:339-341(2004).

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$ 450.00
Cat# ALS14094
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