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MEF2A / MEF2 Antibody (clone 1A10)

Mouse Monoclonal Antibody

     
  • WB - MEF2A / MEF2 Antibody (clone 1A10) ALS14099
    MEF2A monoclonal antibody clone 1A10. Western blot of MEF2A expression in human lung cancer.
  • IF - MEF2A / MEF2 Antibody (clone 1A10) ALS14099
    Immunofluorescence of monoclonal antibody to MEF2A on HeLa cell. [antibody concentration 10 ug/ml].
  • IHC - MEF2A / MEF2 Antibody (clone 1A10) ALS14099
    Anti-MEF2A antibody IHC of human prostate.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q02078
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1A10
Calculated MW 55kDa
Dilution IF (10 µg/ml), IHC-P (2.5 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 4205
Other Names Myocyte-specific enhancer factor 2A, Serum response factor-like protein 1, MEF2A, MEF2
Target/Specificity Human MEF2A
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsMEF2A / MEF2 Antibody (clone 1A10) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MEF2A
Synonyms MEF2
Function Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00251, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:16563226}
Tissue Location Isoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain. Isoform RSRFC4 and isoform RSRFC9 are expressed in all tissues examined
Research Areas
Citations (0)

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Background

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.

References

Pollock R.,et al.Genes Dev. 5:2327-2341(1991).
Treisman R.,et al.Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases.
Yu Y.-T.,et al.Genes Dev. 6:1783-1798(1992).
Suzuki E.,et al.Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 450.00
Cat# ALS14099
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