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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   SMURF1 Antibody (clone 1D7)   

SMURF1 Antibody (clone 1D7)

Mouse Monoclonal Antibody

     
  • WB - SMURF1 Antibody (clone 1D7) ALS14102
    Western blot of SMURF1 expression in Raw 264.7 cells with SMURF1 monoclonal antibody, clone 1D7.
  • WB - SMURF1 Antibody (clone 1D7) ALS14102
    Western blot of SMURF1 expression in transfected 293T cell line by SMURF1 monoclonal antibody,...
  • IF - SMURF1 Antibody (clone 1D7) ALS14102
    Immunofluorescence of monoclonal antibody to SMURF1 on HeLa cell. [antibody concentration 10 ug/ml]
  • IP - SMURF1 Antibody (clone 1D7) ALS14102
    Immunoprecipitation of SMURF1 transfected lysate using anti-SMURF1 monoclonal antibody and...
  • IHC - SMURF1 Antibody (clone 1D7) ALS14102
    Anti-SMURF1 antibody IHC of human prostate.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E, IP
Primary Accession Q9HCE7
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Clone Names 1D7
Calculated MW 86kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml),
Additional Information
Gene ID 57154
Other Names E3 ubiquitin-protein ligase SMURF1, hSMURF1, 6.3.2.-, SMAD ubiquitination regulatory factor 1, SMAD-specific E3 ubiquitin-protein ligase 1, SMURF1, KIAA1625
Target/Specificity Human SMURF1
Reconstitution & Storage Store at -20°C, avoid freeze thaw cycles.
PrecautionsSMURF1 Antibody (clone 1D7) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SMURF1
Synonyms KIAA1625
Function E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side
Tissue Location Expressed in melanocytes (PubMed:23999003).
Research Areas
Citations (0)

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Background

E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA.

References

Nagase T.,et al.DNA Res. 7:273-281(2000).
Liang M.,et al.Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 424:157-164(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Scherer S.W.,et al.Science 300:767-772(2003).

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$ 450.00
Cat# ALS14102
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