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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ATP11B Antibody (N-Terminus)   

ATP11B Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • ICC - ATP11B Antibody (N-Terminus) ALS14118
    Immunocytochemistry of ATP11B in K562 cells with ATP11B antibody at 10 ug/ml.
  • IF - ATP11B Antibody (N-Terminus) ALS14118
    Immunofluorescence of ATP11B in K562 cells with ATP11B antibody at 20 ug/ml.
  • WB - ATP11B Antibody (N-Terminus) ALS14118
    Western blot analysis of ATP11B in K562 cell tissue lysate with ATP11B antibody at 1 ug/ml in...
  • IHC - ATP11B Antibody (N-Terminus) ALS14118
    Anti-ATP11B antibody IHC of human skeletal muscle.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC, E
Primary Accession Q9Y2G3
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 134kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 23200
Other Names Probable phospholipid-transporting ATPase IF, 3.6.3.1, ATPase IR, ATPase class VI type 11B, P4-ATPase flippase complex alpha subunit ATP11B, ATP11B, ATPIF, ATPIR, KIAA0956
Target/Specificity Human ATP11B
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsATP11B Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATP11B
Synonyms ATPIF, ATPIR, KIAA0956
Function Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). Involved in regulation of sensitivity to cisplatin; may contribute to secretory vesicle transport of cisplatin from Golgi to plasma membrane.
Cellular Location Recycling endosome membrane; Multi-pass membrane protein. Early endosome. Endoplasmic reticulum. Golgi apparatus, trans-Golgi network. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, mainly located in recycling endosomes
Research Areas
Citations (0)

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Background

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). Involved in regulation of sensitivity to cisplatin; may contribute to secretory vesicle transport of cisplatin from Golgi to plasma membrane.

References

Halleck M.S.,et al.Physiol. Genomics 1:139-150(1999).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Halleck M.S.,et al.J. Biol. Chem. 277:9736-9740(2002).
Nagase T.,et al.DNA Res. 6:63-70(1999).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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$ 395.00
Cat# ALS14118
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