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ATP11B Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, ICC, E |
|---|---|
| Primary Accession | Q9Y2G3 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 134kDa |
| Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
| Gene ID | 23200 |
|---|---|
| Other Names | Probable phospholipid-transporting ATPase IF, 3.6.3.1, ATPase IR, ATPase class VI type 11B, P4-ATPase flippase complex alpha subunit ATP11B, ATP11B, ATPIF, ATPIR, KIAA0956 |
| Target/Specificity | Human ATP11B |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | ATP11B Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ATP11B |
|---|---|
| Synonyms | ATPIF, ATPIR, KIAA0956 |
| Function | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes (PubMed:30018401). May contribute to the maintenance of membrane lipid asymmetry in endosome compartment (PubMed:30018401). |
| Cellular Location | Recycling endosome membrane; Multi-pass membrane protein. Early endosome. Endoplasmic reticulum. Golgi apparatus, trans-Golgi network. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B (PubMed:21914794). In the presence of TMEM30A, mainly located in recycling endosomes (PubMed:21914794). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). Involved in regulation of sensitivity to cisplatin; may contribute to secretory vesicle transport of cisplatin from Golgi to plasma membrane.
References
Halleck M.S.,et al.Physiol. Genomics 1:139-150(1999).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Halleck M.S.,et al.J. Biol. Chem. 277:9736-9740(2002).
Nagase T.,et al.DNA Res. 6:63-70(1999).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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