|Application ||WB, IHC-P, E|
|Reactivity||Human, Monkey, Bovine, Dog|
|Dilution||ELISA (1:16000), IHC-P (10 µg/ml), WB (1-3 µg/ml)|
|Other Names||Phosphatidylinositol 3, 4, 5-trisphosphate-dependent Rac exchanger 1 protein, P-Rex1, PtdIns(3, 4, 5)-dependent Rac exchanger 1, PREX1, KIAA1415|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||PREX1 / P-REX1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.|
|Cellular Location||Cytoplasm, cytosol. Cell membrane. Note=Mainly cytosolic. Some amount is apparently associated to the plasma membrane|
|Tissue Location||Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues|
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Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Welch H.C.E.,et al.Cell 108:809-821(2002).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 7:65-73(2000).
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