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PREX1 / P-REX1 Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - PREX1 / P-REX1 Antibody (Internal) ALS14136
    PREX1 antibody (1 ug/ml) staining of Human Temporal Cortex lysate (35 ug protein/ml in RIPA buffer).
  • IHC - PREX1 / P-REX1 Antibody (Internal) ALS14136
    Anti-PREX1 antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q8TCU6
Reactivity Human, Monkey, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 186kDa
Dilution ELISA (1:16000), IHC-P (10 µg/ml), WB (1-3 µg/ml)
Additional Information
Gene ID 57580
Other Names Phosphatidylinositol 3, 4, 5-trisphosphate-dependent Rac exchanger 1 protein, P-Rex1, PtdIns(3, 4, 5)-dependent Rac exchanger 1, PREX1, KIAA1415
Target/Specificity Human PREX1.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsPREX1 / P-REX1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PREX1
Synonyms KIAA1415
Function Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Cellular Location Cytoplasm, cytosol. Cell membrane. Note=Mainly cytosolic. Some amount is apparently associated to the plasma membrane
Tissue Location Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues
Volume 50 µl
Research Areas
Citations (0)

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Background

Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.

References

Welch H.C.E.,et al.Cell 108:809-821(2002).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 7:65-73(2000).

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$ 395.00
Cat# ALS14136
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