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RGS3 Antibody (clone 1E8-C7)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | P49796 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 1E8-C7 |
| Calculated MW | 132kDa |
| Dilution | IF (10 µg/ml), IHC-P (5 µg/ml), |
| Gene ID | 5998 |
|---|---|
| Other Names | Regulator of G-protein signaling 3, RGP3, RGS3, RGS3 |
| Target/Specificity | Human RGS3 |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | RGS3 Antibody (clone 1E8-C7) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RGS3 |
|---|---|
| Function | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein- mediated release of inositol phosphates and activation of MAP kinases. |
| Cellular Location | Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Long isoforms are cytoplasmic and associated with the plasma membrane (PubMed:9858594). Short isoforms are nuclear (PubMed:10749886) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G- protein-mediated release of inositol phosphates and activation of MAP kinases.
References
Druey K.M.,et al.Nature 379:742-746(1996).
Kehrl J.H.,et al.Genomics 79:860-868(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Chatterjee T.K.,et al.Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
Puhl H.L. III,et al.Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
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