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RGS3 Antibody (clone 1E8-C7)

Mouse Monoclonal Antibody

     
  • WB - RGS3 Antibody (clone 1E8-C7) ALS14148
    Western blot of RGS3 expression in transfected 293T cell line by RGS3 monoclonal antibody clone...
  • IF - RGS3 Antibody (clone 1E8-C7) ALS14148
    Immunofluorescence of monoclonal antibody to RGS3 on HeLa cell. [antibody concentration 10 ug/ml].
  • IHC - RGS3 Antibody (clone 1E8-C7) ALS14148
    Anti-RGS3 antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P49796
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1E8-C7
Calculated MW 132kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml),
Additional Information
Gene ID 5998
Other Names Regulator of G-protein signaling 3, RGP3, RGS3, RGS3
Target/Specificity Human RGS3
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsRGS3 Antibody (clone 1E8-C7) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RGS3
Function Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G- protein-mediated release of inositol phosphates and activation of MAP kinases.
Cellular Location Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Long isoforms are cytoplasmic and associated with the plasma membrane (PubMed:9858594). Short isoforms are nuclear (PubMed:10749886)
Research Areas
Citations (0)

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Background

Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G- protein-mediated release of inositol phosphates and activation of MAP kinases.

References

Druey K.M.,et al.Nature 379:742-746(1996).
Kehrl J.H.,et al.Genomics 79:860-868(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Chatterjee T.K.,et al.Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
Puhl H.L. III,et al.Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.

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$ 450.00
Cat# ALS14148
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