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STAT4 Antibody (clone 1C2-1C12)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E, IP |
|---|---|
| Primary Accession | Q14765 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 1C2-1C12 |
| Calculated MW | 86kDa |
| Dilution | IF (10 µg/ml), IHC-P (5 µg/ml), |
| Gene ID | 6775 |
|---|---|
| Other Names | Signal transducer and activator of transcription 4, STAT4 |
| Target/Specificity | Human STAT4 |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | STAT4 Antibody (clone 1C2-1C12) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STAT4 |
|---|---|
| Function | Transcriptional regulator mainly expressed in hematopoietic cells that plays a critical role in cellular growth, differentiation and immune response (PubMed:8943379, PubMed:10961885, PubMed:37256972). Plays a key role in the differentiation of T-helper 1 cells and the production of interferon-gamma (PubMed:12213961, PubMed:35614130). Participates also in multiple neutrophil functions including chemotaxis and production of the neutrophil extracellular traps (By similarity). After IL12 binding to its receptor IL12RB2, STAT4 interacts with the intracellular domain of IL12RB2 and becomes tyrosine phosphorylated (PubMed:7638186, PubMed:10415122). Phosphorylated STAT4 then homodimerizes and migrates to the nucleus where it can recognize STAT target sequences present in IL12 responsive genes. Although IL12 appears to be the predominant activating signal, STAT4 can also be phosphorylated and activated in response to IFN-gamma stimulation via JAK1 and TYK2 and in response to different interleukins including IL23, IL2 and IL35 (PubMed:11114383, PubMed:34508746). Transcription activation of IFN-gamma gene is mediated by interaction with JUN that forms a complex that efficiently interacts with the AP-1-related sequence of the IFN-gamma promoter (By similarity). In response to IFN- alpha/beta signaling, acts as a transcriptional repressor and suppresses IL5 and IL13 mRNA expression during response to T-cell receptor (TCR) activation (PubMed:26990433). |
| Cellular Location | Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.
References
Xu X.,et al.Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
Yao B.B.,et al.Arch. Biochem. Biophys. 368:147-155(1999).
Naeger L.K.,et al.J. Biol. Chem. 274:1875-1878(1999).
Kariuki S.N.,et al.J. Immunol. 182:34-38(2009).
Sjoeblom T.,et al.Science 314:268-274(2006).
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