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STAT5B Antibody (clone 2D1)

Mouse Monoclonal Antibody

     
  • WB - STAT5B Antibody (clone 2D1) ALS14161
    STAT5B monoclonal antibody clone 2D1 Western blot of STAT5B expression in HeLa.
  • IF - STAT5B Antibody (clone 2D1) ALS14161
    Immunofluorescence of monoclonal antibody to STAT5B on HeLa cell. [antibody concentration 10 ug/ml]
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P51692
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2D1
Calculated MW 90kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml),
Additional Information
Gene ID 6777
Other Names Signal transducer and activator of transcription 5B, STAT5B
Target/Specificity Human STAT5b
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsSTAT5B Antibody (clone 2D1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STAT5B
Function Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription (PubMed:11773439). Positively regulates hematopoietic/erythroid differentiation (PubMed:20702587).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:P42232}. Nucleus {ECO:0000250|UniProtKB:P42232}. Note=Translocated into the nucleus in response to phosphorylation.
Research Areas
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Background

Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription.

References

Silva C.M.,et al.Mol. Endocrinol. 10:508-518(1996).
Silva C.M.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Lin J.-X.,et al.J. Biol. Chem. 271:10738-10744(1996).
Ambrosio R.,et al.Gene 285:311-318(2002).
Sawka-Verhelle D.,et al.Eur. J. Biochem. 250:411-417(1997).

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$ 450.00
Cat# ALS14161
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