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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   STXBP1 / MUNC18-1 Antibody (clone 6D1)   

STXBP1 / MUNC18-1 Antibody (clone 6D1)

Mouse Monoclonal Antibody

     
  • WB - STXBP1 / MUNC18-1 Antibody (clone 6D1) ALS14162
    STXBP1 monoclonal antibody clone 6D1 Western blot of STXBP1 expression in HeLa.
  • WB - STXBP1 / MUNC18-1 Antibody (clone 6D1) ALS14162
    STXBP1 monoclonal antibody clone 6D1. Western blot of STXBP1 expression in NIH/3T3.
  • IHC - STXBP1 / MUNC18-1 Antibody (clone 6D1) ALS14162
    Anti-STXBP1 antibody IHC of human pancreas, islets of Langerhans.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P61764
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Clone Names 6D1
Calculated MW 68kDa
Dilution IHC-P (5 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 6812
Other Names Syntaxin-binding protein 1, MUNC18-1, N-Sec1, Protein unc-18 homolog 1, Unc18-1, Protein unc-18 homolog A, Unc-18A, p67, STXBP1, UNC18A
Target/Specificity Human STXBP1
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsSTXBP1 / MUNC18-1 Antibody (clone 6D1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STXBP1
Synonyms UNC18A
Function May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
Cellular Location Cytoplasm, cytosol. Membrane; Peripheral membrane protein
Tissue Location Brain and spinal cord. Highly enriched in axons
Research Areas
Citations (0)

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Background

May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.

References

Gengyo-Ando K.,et al.J. Neurosci. 16:6695-6702(1996).
Swanson D.A.,et al.Genomics 48:373-376(1998).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Tian J.H.,et al.J. Biol. Chem. 278:26265-26274(2003).

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$ 450.00
Cat# ALS14162
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