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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   TSG101 Antibody (clone 5B7)   

TSG101 Antibody (clone 5B7)

Mouse Monoclonal Antibody

     
  • WB - TSG101 Antibody (clone 5B7) ALS14166
    TSG101 monoclonal antibody clone 5B7 Western blot of TSG101 expression in K-562.
  • IF - TSG101 Antibody (clone 5B7) ALS14166
    Immunofluorescence of monoclonal antibody to TSG101 on HeLa cell. [antibody concentration 10 ug/ml]
  • IHC - TSG101 Antibody (clone 5B7) ALS14166
    Anti-TSG101 antibody IHC of human skin.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q99816
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 5B7
Calculated MW 44kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 7251
Other Names Tumor susceptibility gene 101 protein, ESCRT-I complex subunit TSG101, TSG101
Target/Specificity Human TSG101
Reconstitution & Storage Long term: -20°C; Short term: -20°C
PrecautionsTSG101 Antibody (clone 5B7) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TSG101
Function Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Late endosome membrane; Peripheral membrane protein. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Depending on the stage of the cell cycle, detected in the nucleus. Colocalized with CEP55 in the midbody during cytokinesis
Tissue Location Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas
Research Areas
Citations (0)

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Background

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.

References

Li L.,et al.Cell 88:143-154(1997).
Li L.,et al.Cell 93:661-661(1998).
Gayther S.A.,et al.Oncogene 15:2119-2126(1997).
Lee M.P.,et al.Cancer Res. 57:3131-3134(1997).
Wagner K.-U.,et al.Oncogene 17:2761-2770(1998).

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$ 450.00
Cat# ALS14166
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