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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   UBE2D2 / UBCH5B Antibody (clone 4A1)   

UBE2D2 / UBCH5B Antibody (clone 4A1)

Mouse Monoclonal Antibody

     
  • WB - UBE2D2 / UBCH5B Antibody (clone 4A1) ALS14167
    UBE2D2 monoclonal antibody clone 4A1. Western blot of UBE2D2 expression in PC-12.
  • WB - UBE2D2 / UBCH5B Antibody (clone 4A1) ALS14167
    UBE2D2 monoclonal antibody clone 4A1 Western blot of UBE2D2 expression in NIH/3T3.
  • IHC - UBE2D2 / UBCH5B Antibody (clone 4A1) ALS14167
    Anti-UBE2D2 antibody IHC of human skin.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P62837
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Clone Names 4A1
Calculated MW 17kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 7322
Other Names Ubiquitin-conjugating enzyme E2 D2, 6.3.2.19, Ubiquitin carrier protein D2, Ubiquitin-conjugating enzyme E2(17)KB 2, Ubiquitin-conjugating enzyme E2-17 kDa 2, Ubiquitin-protein ligase D2, p53-regulated ubiquitin-conjugating enzyme 1, UBE2D2, PUBC1, UBC4, UBC5B, UBCH4, UBCH5B
Target/Specificity Human UBE2D2
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsUBE2D2 / UBCH5B Antibody (clone 4A1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBE2D2
Synonyms PUBC1, UBC4, UBC5B, UBCH4, UBCH5B
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.
Research Areas
Citations (0)

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Background

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.

References

Jensen J.P.,et al.J. Biol. Chem. 270:30408-30414(1995).
Rolfe M.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:3264-3268(1995).
Guinn B.-A.,et al.Biochem. Biophys. Res. Commun. 335:1293-1304(2005).
Yin Y.,et al.Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 450.00
Cat# ALS14167
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