KRT8 / CK8 / Cytokeratin 8 Antibody (clone C-51)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IHC-P, IHC-F |
---|---|
Primary Accession | P05787 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | C-51 |
Calculated MW | 54kDa |
Dilution | IHC-P (1:50) |
Gene ID | 3856 |
---|---|
Other Names | Keratin, type II cytoskeletal 8, Cytokeratin-8, CK-8, Keratin-8, K8, Type-II keratin Kb8, KRT8, CYK8 |
Target/Specificity | For frozen and paraffin embedded tissues the optimal dilutions have to be determined for use within each laboratory. |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | KRT8 / CK8 / Cytokeratin 8 Antibody (clone C-51) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KRT8 |
---|---|
Synonyms | CYK8 |
Function | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. |
Cellular Location | Cytoplasm. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q10758}. Nucleus matrix {ECO:0000250|UniProtKB:Q10758} |
Tissue Location | Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
References
Krauss S.,et al.Gene 86:241-249(1990).
Yamamoto R.,et al.Mol. Endocrinol. 4:370-374(1990).
Waseem A.,et al.New Biol. 2:464-478(1990).
Ku N.-O.,et al.J. Biol. Chem. 272:7556-7564(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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