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> home > Products > Primary Antibodies > Signal Transduction > Mucin 2 / MUC2 Antibody (clone Ccp58)
Mucin 2 / MUC2 Antibody (clone Ccp58)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E, IHC-Fr, Flo |
|---|---|
| Primary Accession | Q02817 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | Ccp58 |
| Calculated MW | 540kDa |
| Dilution | IHC-P (1:100) |
| Gene ID | 4583 |
|---|---|
| Other Names | Mucin-2, MUC-2, Intestinal mucin-2, MUC2, SMUC |
| Target/Specificity | Reacts with colon gastric cancer cells, normal intestine, colon and salivary gland (immunoperoxidase staining); human colon cancer cell line LS174T by flow cytometry & Western blotting. Epitope defined as -GTQTP- (GlyThrGlnThrPro). |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | Mucin 2 / MUC2 Antibody (clone Ccp58) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MUC2 {ECO:0000303|PubMed:8300571, ECO:0000312|HGNC:HGNC:7512} |
|---|---|
| Function | Coats the epithelia of the intestines and other mucus membrane-containing organs to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (PubMed:17058067, PubMed:19432394, PubMed:33031746). Major constituent of the colon mucus, which is mainly formed by large polymeric networks of MUC2 secreted by goblet cells that cover the exposed surfaces of intestine (PubMed:19432394, PubMed:33031746). MUC2 networks form hydrogels that guard the underlying epithelium from pathogens and other hazardous matter entering from the outside world, while permitting nutrient absorption and gas exchange (PubMed:33031746, PubMed:36206754). Acts as a divalent copper chaperone that protects intestinal cells from copper toxicity and facilitates nutritional copper unptake into cells (PubMed:36206754). Binds both Cu(2+) and its reduced form, Cu(1+), at two juxtaposed binding sites: Cu(2+), once reduced to Cu(1+) by vitamin C (ascorbate) or other dietary antioxidants, transits to the other binding site (PubMed:36206754). MUC2-bound Cu(1+) is protected from oxidation in aerobic environments, and can be released for nutritional delivery to cells (PubMed:36206754). Mucin gels store antimicrobial molecules that participate in innate immunity (PubMed:33031746). Mucin glycoproteins also house and feed the microbiome, lubricate tissue surfaces, and may facilitate the removal of contaminants and waste products from the body (PubMed:33031746). Goblet cells synthesize two forms of MUC2 mucin that differ in branched chain O-glycosylation and the site of production in the colon: a (1) 'thick' mucus that wraps the microbiota to form fecal pellets is produced in the proximal, ascending colon (By similarity). 'Thick' mucus transits along the descending colon and is lubricated by a (2) 'thin' MUC2 mucus produced in the distal colon which adheres to the 'thick' mucus (By similarity). |
| Cellular Location | Secreted. Note=In the intestine, secreted into the inner and outer mucus layers (By similarity). Before secretion, mucin polymers are stored in dedicated secretory vesicles (PubMed:33031746). {ECO:0000250|UniProtKB:Q80Z19, ECO:0000269|PubMed:33031746} |
| Tissue Location | Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder. |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.
References
Gum J.R. Jr.,et al.J. Biol. Chem. 269:2440-2446(1994).
Gum J.R. Jr.,et al.J. Biol. Chem. 267:21375-21383(1992).
Toribara N.W.,et al.J. Clin. Invest. 88:1005-1013(1991).
Gum J.R. Jr.,et al.J. Biol. Chem. 264:6480-6487(1989).
Xu G.,et al.Biochem. Biophys. Res. Commun. 183:821-828(1992).
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$ 467.50
Cat# ALS14176
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