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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CHGA / Chromogranin A Antibody (clone LK2H10)   

CHGA / Chromogranin A Antibody (clone LK2H10)

Mouse Monoclonal Antibody

  • IHC - CHGA / Chromogranin A Antibody (clone LK2H10) ALS14183
    Anti-CHGA / Chromogranin A antibody IHC of human intestine.
  • IHC - CHGA / Chromogranin A Antibody (clone LK2H10) ALS14183
    Anti-CHGA / Chromogranin A antibody IHC of human pancreas, islets of Langerhans.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P10645
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names LK2H10
Calculated MW 51kDa
Dilution IHC-P (1:100)
Additional Information
Gene ID 1113
Other Names Chromogranin-A, CgA, Pituitary secretory protein I, SP-I, Vasostatin-1, Vasostatin I, Vasostatin-2, Vasostatin II, EA-92, ES-43, Pancreastatin, SS-18, WA-8, WE-14, LF-19, AL-11, GV-19, GR-44, ER-37, CHGA
Target/Specificity The antibody is specific for chromogranin A. Specificity was ascertained by immunoblotting and immunohistochemistry. The antibody predominantly reacts with a 68 kD protein. Antigen was isolated from human Pheochromocytoma. Antigen location, cytoplasm ...
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsCHGA / Chromogranin A Antibody (clone LK2H10) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas. Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
Cellular Location Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle membrane. Secreted. Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions.
Tissue Location GE-25 is found in the brain.
Volume 50 µl
Research Areas
Citations (0)

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Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.


Konecki D.S.,et al.J. Biol. Chem. 262:17026-17030(1987).
Helman L.J.,et al.J. Biol. Chem. 263:11559-11563(1988).
Mouland A.J.,et al.J. Biol. Chem. 269:6918-6926(1994).
Mouland A.J.,et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS14183
(40 western blots)
Availability: 5 days
Bulk Size
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