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STXBP1 / MUNC18-1 Antibody (aa279-328)

Rabbit Polyclonal Antibody

     
  • IF - STXBP1 / MUNC18-1 Antibody (aa279-328) ALS14186
    Immunofluorescence of NIH-3T3 cells, using MUNC-18a Antibody.
  • IHC - STXBP1 / MUNC18-1 Antibody (aa279-328) ALS14186
    Anti-STXBP1 antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, E
Primary Accession P61764
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 68kDa
Dilution ELISA (1:40000), IF (1:100-1:500), IHC-P (10 µg/ml)
Additional Information
Gene ID 6812
Other Names Syntaxin-binding protein 1, MUNC18-1, N-Sec1, Protein unc-18 homolog 1, Unc18-1, Protein unc-18 homolog A, Unc-18A, p67, STXBP1, UNC18A
Target/Specificity MUNC-18a Antibody detects endogenous levels of total MUNC-18a protein.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsSTXBP1 / MUNC18-1 Antibody (aa279-328) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STXBP1
Synonyms UNC18A
Function May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
Cellular Location Cytoplasm, cytosol. Membrane; Peripheral membrane protein
Tissue Location Brain and spinal cord. Highly enriched in axons
Volume 50 µl
Research Areas
Citations (0)

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Background

May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.

References

Gengyo-Ando K.,et al.J. Neurosci. 16:6695-6702(1996).
Swanson D.A.,et al.Genomics 48:373-376(1998).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Tian J.H.,et al.J. Biol. Chem. 278:26265-26274(2003).

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$ 395.00
Cat# ALS14186
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