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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   IGF2R / CD222 Antibody (aa2441-2490)   

IGF2R / CD222 Antibody (aa2441-2490)

Rabbit Polyclonal Antibody

     
  • IF - IGF2R / CD222 Antibody (aa2441-2490) ALS14189
    Immunofluorescence of HeLa cells, using IGF2R Antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, E
Primary Accession P11717
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 274kDa
Dilution ELISA (1:20000), IF (1:100-1:500), IHC-P (10 µg/ml)
Additional Information
Gene ID 3482
Other Names Cation-independent mannose-6-phosphate receptor, CI Man-6-P receptor, CI-MPR, M6PR, 300 kDa mannose 6-phosphate receptor, MPR 300, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, IGF-II receptor, M6P/IGF2 receptor, M6P/IGF2R, CD222, IGF2R, MPRI
Target/Specificity IGF2R Antibody detects endogenous levels of total IGF2R protein.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsIGF2R / CD222 Antibody (aa2441-2490) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IGF2R
Synonyms MPRI
Function Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.
Cellular Location Lysosome membrane; Single-pass type I membrane protein. Note=Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface
Volume 50 µl
Research Areas
Citations (0)

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Background

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.

References

Morgan D.O.,et al.Nature 329:301-307(1987).
Oshima A.,et al.J. Biol. Chem. 263:2553-2562(1988).
Gemma A.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Killian J.K.,et al.Mamm. Genome 10:74-77(1999).
Mungall A.J.,et al.Nature 425:805-811(2003).

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$ 395.00
Cat# ALS14189
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