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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HRS / HGS Antibody (aa451-500)   

HRS / HGS Antibody (aa451-500)

Rabbit Polyclonal Antibody

     
  • IF - HRS / HGS Antibody (aa451-500) ALS14199
    Immunofluorescence of HUVEC cells, using HGS Antibody.
  • IHC - HRS / HGS Antibody (aa451-500) ALS14199
    Anti-HGS antibody IHC of human liver.
  • IHC - HRS / HGS Antibody (aa451-500) ALS14199
    Anti-HGS antibody IHC of human pancreas, islets of Langerhans.
  • IHC - HRS / HGS Antibody (aa451-500) ALS14199
    Anti-HGS antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession O14964
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 86kDa
Dilution ELISA (1:40000), IF (1:100-1:500), IHC-P (10 µg/ml), WB (1:500-1:1000) ,
Additional Information
Gene ID 9146
Other Names Hepatocyte growth factor-regulated tyrosine kinase substrate, Hrs, Protein pp110, HGS, HRS
Target/Specificity HGS Antibody detects endogenous levels of total HGS protein.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsHRS / HGS Antibody (aa451-500) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HGS
Synonyms HRS
Function Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
Cellular Location Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Endosome, multivesicular body membrane; Peripheral membrane protein. Note=Colocalizes with UBQLN1 in ubiquitin- rich cytoplasmic aggregates that are not endocytic compartments
Tissue Location Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes.
Volume 50 µl
Research Areas
Citations (0)

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Background

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.

References

Asao H.,et al.J. Biol. Chem. 272:32785-32791(1997).
Lu L.,et al.Gene 213:125-132(1998).
Scoles D.R.,et al.Hum. Mol. Genet. 9:1567-1574(2000).
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Komada M.,et al.J. Biol. Chem. 272:20538-20544(1997).

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$ 395.00
Cat# ALS14199
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