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ATXN1 / SCA1 Antibody (aa742-791)

Rabbit Polyclonal Antibody

     
  • IF - ATXN1 / SCA1 Antibody (aa742-791) ALS14209
    Immunofluorescence of NIH-3T3 cells, using Ataxin 1 (Ab-776) Antibody.
  • IHC - ATXN1 / SCA1 Antibody (aa742-791) ALS14209
    Anti-ATXN1 / Ataxin-1 antibody IHC of human pancreas.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, E
Primary Accession P54253
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 87kDa
Dilution ELISA (1:5000), IF (1:100-1:500), IHC-P (5 µg/ml)
Additional Information
Gene ID 6310
Other Names Ataxin-1, Spinocerebellar ataxia type 1 protein, ATXN1, ATX1, SCA1
Target/Specificity Ataxin 1 (Ab-776) Antibody detects endogenous levels of total Ataxin 1 protein.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsATXN1 / SCA1 Antibody (aa742-791) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATXN1
Synonyms ATX1, SCA1
Function Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism.
Cellular Location Cytoplasm. Nucleus Note=Colocalizes with USP7 in the nucleus
Tissue Location Widely expressed throughout the body.
Volume 50 µl
Research Areas
Citations (0)

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Background

Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function.

References

Banfi S.,et al.Nat. Genet. 7:513-519(1994).
Mungall A.J.,et al.Nature 425:805-811(2003).
Quan F.,et al.Hum. Mol. Genet. 4:2411-2413(1995).
Burright E.N.,et al.Hum. Mol. Genet. 6:513-518(1997).
Matilla A.,et al.Nature 389:974-978(1997).

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$ 395.00
Cat# ALS14209
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