|Application ||IHC-P, IF, E|
|Dilution||ELISA (1:5000), IF (1:100-1:500), IHC-P (5 µg/ml)|
|Other Names||Ataxin-1, Spinocerebellar ataxia type 1 protein, ATXN1, ATX1, SCA1|
|Target/Specificity||Ataxin 1 (Ab-776) Antibody detects endogenous levels of total Ataxin 1 protein.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||ATXN1 / SCA1 Antibody (aa742-791) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function.|
|Cellular Location||Cytoplasm. Nucleus. Note=Colocalizes with USP7 in the nucleus|
|Tissue Location||Widely expressed throughout the body.|
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Provided below are standard protocols that you may find useful for product applications.
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function.
Banfi S.,et al.Nat. Genet. 7:513-519(1994).
Mungall A.J.,et al.Nature 425:805-811(2003).
Quan F.,et al.Hum. Mol. Genet. 4:2411-2413(1995).
Burright E.N.,et al.Hum. Mol. Genet. 6:513-518(1997).
Matilla A.,et al.Nature 389:974-978(1997).
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