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VWF / Von Willebrand Factor Antibody (FITC)

Sheep Polyclonal Antibody

     
  • IHC - VWF / Von Willebrand Factor Antibody (FITC) ALS14216
    Anti-VWF antibody IHC of human spleen, endothelium.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, IHC-Fr
Primary Accession P04275
Reactivity Human
Host Sheep
Clonality Polyclonal
Calculated MW 309kDa
Dilution IF (1:25-1:50), IHC-P (1:200),
Additional Information
Gene ID 7450
Other Names von Willebrand factor, vWF, von Willebrand antigen 2, von Willebrand antigen II, VWF, F8VWF
Target/Specificity Recognizes human Von Willebrand Factor (vWF). No arcs when tested by IEP against human serum. Identity has been confirmed by double diffusion (Ouchterlony) vs. human vWF and an anti-human vWF of known specificity.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsVWF / Von Willebrand Factor Antibody (FITC) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VWF
Synonyms F8VWF
Function Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
Cellular Location Secreted. Secreted, extracellular space, extracellular matrix. Note=Localized to storage granules
Tissue Location Plasma.
Research Areas
Citations (0)

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Background

Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.

References

Bonthron D.,et al.Nucleic Acids Res. 14:7125-7128(1986).
Mancuso D.J.,et al.J. Biol. Chem. 264:19514-19527(1989).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Verweij C.L.,et al.EMBO J. 5:1839-1847(1986).

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$ 450.00
Cat# ALS14216
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