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SYT1 / Synaptotagmin Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P21579 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Hamster, Monkey, Pig, Chicken, Horse, Bovine, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 48kDa |
| Dilution | ELISA (1:2000), IHC-P (3.75 µg/ml), WB (0.3-1 µg/ml) |
| Gene ID | 6857 |
|---|---|
| Other Names | Synaptotagmin-1, Synaptotagmin I, SytI, p65, SYT1, SVP65, SYT |
| Target/Specificity | Human SYT1 / Synaptotagmin. Reported isoforms NP_005630.1, NP_001129277.1 and NP_001129278.1 represent identical protein. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | SYT1 / Synaptotagmin Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SYT1 (HGNC:11509) |
|---|---|
| Synonyms | SVP65, SYT |
| Function | Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)- dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003). |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P21707}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P21707}. Cytoplasm {ECO:0000250|UniProtKB:P21707} |
| Tissue Location | Expressed in melanocytes (PubMed:23999003). |
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Provided below are standard protocols that you may find useful for product applications.
Background
May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
References
Perin M.S.,et al.J. Biol. Chem. 266:615-622(1991).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Han C.,et al.J. Immunol. 182:2986-2996(2009).
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