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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   DGAT1 Antibody (Internal)   

DGAT1 Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - DGAT1 Antibody (Internal) ALS14254
    Anti-DGAT1 antibody IHC of human colon, ganglion.
  • WB - DGAT1 Antibody (Internal) ALS14254
    Staining (0.3 ug/ml) of rat duodenum lysate (35 ug protein in RIPA buffer).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O75907
Reactivity Human, Mouse, Rat, Hamster, Monkey, Pig, Goat, Sheep, Horse, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 55kDa
Dilution ELISA (1:64000), IHC-P (3.75 µg/ml), WB (0.3-1 µg/ml)
Additional Information
Gene ID 8694
Other Names Diacylglycerol O-acyltransferase 1, 2.3.1.20, ACAT-related gene product 1, Acyl-CoA retinol O-fatty-acyltransferase, ARAT, Retinol O-fatty-acyltransferase, 2.3.1.76, Diglyceride acyltransferase, DGAT1, AGRP1, DGAT
Target/Specificity Human DGAT1.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsDGAT1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DGAT1
Synonyms AGRP1, DGAT
Function Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.
Cellular Location Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z2A7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Z2A7}
Research Areas
Citations (0)

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Background

Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.

References

Oelkers P.,et al.J. Biol. Chem. 273:26765-26771(1998).
Yamasaki Y.,et al.Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Orland M.D.,et al.Biochim. Biophys. Acta 1737:76-82(2005).
Haas J.T.,et al.J. Clin. Invest. 122:4680-4684(2012).

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$ 395.00
Cat# ALS14254
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