|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rabbit, Pig, Goat, Horse, Bovine, Dog|
|Dilution||ELISA (1:8000), IHC-P (3.75 µg/ml), WB (0.1-0.3 µg/ml)|
|Other Names||Neurogranin, Ng, RC3, NEUG(55-78), NRGN|
|Target/Specificity||Human NRGN / Neurogranin. Reported variants represent identical protein: NP_006167.1, NP_001119653.1|
|Reconstitution & Storage||Long term: -70°C; Short term: -20°C; Avoid freeze-thaw cycles.|
|Precautions||NRGN / Neurogranin Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).|
|Tissue Location||In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease.|
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Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).
Mertsalov I.B.,et al.Bioorg. Khim. 22:366-369(1996).
Mertsalov I.B.,et al.Bioorg. Khim. 23:961-968(1997).
Martinez de Arrieta C.,et al.Genomics 41:243-249(1997).
Chang J.W.,et al.J. Neuropathol. Exp. Neurol. 56:1105-1118(1997).
Mertsalov I.B.,et al.Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
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