|Application ||WB, IHC-P, E|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||High affinity cGMP-specific 3', 5'-cyclic phosphodiesterase 9A, 220.127.116.11, PDE9A|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||PDE9A Antibody (clone 1E1) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.|
|Cellular Location||Isoform PDE9A1: Cell projection, ruffle membrane. Cytoplasm, perinuclear region. Golgi apparatus Endoplasmic reticulum Isoform PDE9A3: Cytoplasm. Endoplasmic reticulum|
|Tissue Location||Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood. Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate|
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Provided below are standard protocols that you may find useful for product applications.
Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.
Fisher D.A.,et al.J. Biol. Chem. 273:15559-15564(1998).
Guipponi M.,et al.Hum. Genet. 103:386-392(1998).
Rentero C.,et al.Biochem. Biophys. Res. Commun. 301:686-692(2003).
Wang P.,et al.Gene 314:15-27(2003).
Rentero C.,et al.BMC Mol. Biol. 7:39-39(2006).
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