|Application ||IHC-P, Flo|
|Reactivity||Human, Rat, Pig|
|Clone Names||IT-Ks 20.10|
|Other Names||Keratin, type I cytoskeletal 20, Cytokeratin-20, CK-20, Keratin-20, K20, Protein IT, KRT20|
|Target/Specificity||Human, pig, and rat. Polypeptide reacting: Protein IT Reactivities on cultured Cell lines that have been tested so far are HT-29, LoVo, DLD-1, SW 1116 CaCo-2, RT-4.|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||KRT20 / CK20 / Cytokeratin 20 Antibody (clone IT-Ks 20.10, FITC) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).|
|Tissue Location||Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa.|
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Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).
Moll R.,et al.Differentiation 53:75-93(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zhou Q.,et al.J. Biol. Chem. 281:16453-16461(2006).
Calnek D.,et al.Differentiation 53:95-104(1993).
Moll R.,et al.J. Cell Biol. 111:567-580(1990).
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