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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ARNT / HIF-1-Beta Antibody (clone 3D10)   

ARNT / HIF-1-Beta Antibody (clone 3D10)

Mouse Monoclonal Antibody

     
  • WB - ARNT / HIF-1-Beta Antibody (clone 3D10) ALS14310
    Western blot of ARNT expression in HeLa nuclear extract.
  • WB - ARNT / HIF-1-Beta Antibody (clone 3D10) ALS14310
    Western blot of ARNT expression in transfected 293T cell line.
  • IF - ARNT / HIF-1-Beta Antibody (clone 3D10) ALS14310
    Immunofluorescence of monoclonal antibody to ARNT on HeLa cell. [antibody concentration 10 ug/ml]
  • IHC - ARNT / HIF-1-Beta Antibody (clone 3D10) ALS14310
    Anti-ARNT antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P27540
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3D10
Calculated MW 87kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 405
Other Names Aryl hydrocarbon receptor nuclear translocator, ARNT protein, Class E basic helix-loop-helix protein 2, bHLHe2, Dioxin receptor, nuclear translocator, Hypoxia-inducible factor 1-beta, HIF-1-beta, HIF1-beta, ARNT, BHLHE2
Target/Specificity Human ARNT
Reconstitution & Storage Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
PrecautionsARNT / HIF-1-Beta Antibody (clone 3D10) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARNT
Synonyms BHLHE2
Function Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.

References

Hoffman E.C.,et al.Science 252:954-958(1991).
Scheel J.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Wiemann S.,et al.Genome Res. 11:422-435(2001).

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$ 450.00
Cat# ALS14310
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