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ATP2A3 / SERCA3 Antibody (clone 2H3)

Mouse Monoclonal Antibody

     
  • WB - ATP2A3 / SERCA3 Antibody (clone 2H3) ALS14313
    Western blot of ATP2A3 expression in HL-60 cell lysate.
  • IHC - ATP2A3 / SERCA3 Antibody (clone 2H3) ALS14313
    Anti-ATP2A3 / SERCA3 antibody IHC of human brain, cerebellum.
  • IHC - ATP2A3 / SERCA3 Antibody (clone 2H3) ALS14313
    Anti-ATP2A3 / SERCA3 antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q93084
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2H3
Calculated MW 114kDa
Dilution IHC-P (5 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 489
Other Names Sarcoplasmic/endoplasmic reticulum calcium ATPase 3, SERCA3, SR Ca(2+)-ATPase 3, 3.6.3.8, Calcium pump 3, ATP2A3
Target/Specificity Human ATP2A3
Reconstitution & Storage Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
PrecautionsATP2A3 / SERCA3 Antibody (clone 2H3) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATP2A3
Function This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
Cellular Location Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Found in most tissues. Most abundant in thymus, trachea, salivary gland, spleen, bone marrow, lymph node, peripheral leukocytes, pancreas and colon. Also detected in fetal tissues. Expressed in cell lineages of hematopoietic, epithelial, or embryonic origin and also expressed in several cancer cell lines.
Research Areas
Citations (0)

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Background

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.

References

Dode L.,et al.Biochem. J. 318:689-699(1996).
Dode L.,et al.Biochem. J. 319:1008-1008(1996).
Dode L.,et al.J. Biol. Chem. 273:13982-13994(1998).
Poch E.,et al.Am. J. Physiol. 275:C1449-C1458(1998).
Zody M.C.,et al.Nature 440:1045-1049(2006).

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$ 450.00
Cat# ALS14313
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