|Application ||WB, IHC-P, E|
|Dilution||IHC-P (5 µg/ml), WB (1:500-1:1000),|
|Other Names||Sarcoplasmic/endoplasmic reticulum calcium ATPase 3, SERCA3, SR Ca(2+)-ATPase 3, 188.8.131.52, Calcium pump 3, ATP2A3|
|Reconstitution & Storage||Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.|
|Precautions||ATP2A3 / SERCA3 Antibody (clone 2H3) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.|
|Cellular Location||Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Found in most tissues. Most abundant in thymus, trachea, salivary gland, spleen, bone marrow, lymph node, peripheral leukocytes, pancreas and colon. Also detected in fetal tissues. Expressed in cell lineages of hematopoietic, epithelial, or embryonic origin and also expressed in several cancer cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
Dode L.,et al.Biochem. J. 318:689-699(1996).
Dode L.,et al.Biochem. J. 319:1008-1008(1996).
Dode L.,et al.J. Biol. Chem. 273:13982-13994(1998).
Poch E.,et al.Am. J. Physiol. 275:C1449-C1458(1998).
Zody M.C.,et al.Nature 440:1045-1049(2006).
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