|Application ||WB, IHC-P, E, IP|
|Calculated MW||60587 Da|
|Dilution||IHC-P (5 µg/ml), WB (1:500-1:1000),|
|Other Names||Cystathionine beta-synthase, 188.8.131.52, Beta-thionase, Serine sulfhydrase, CBS|
|Reconstitution & Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||CBS Antibody (clone 3E1) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L- homocysteine (PubMed:23981774, PubMed:20506325, PubMed:23974653). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||In the adult strongly expressed in liver and pancreas, some expression in heart and brain, weak expression in lung and kidney. In the fetus, expressed in brain, liver and kidney|
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