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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   CCNH / Cyclin H Antibody (clone 1B8)   

CCNH / Cyclin H Antibody (clone 1B8)

Mouse Monoclonal Antibody

     
  • WB - CCNH / Cyclin H Antibody (clone 1B8) ALS14322
    Western blot of CCNH expression in HeLa cell lysate.
  • WB - CCNH / Cyclin H Antibody (clone 1B8) ALS14322
    Western blot of CCNH expression in transfected 293T cell line.
  • IF - CCNH / Cyclin H Antibody (clone 1B8) ALS14322
    Immunofluorescence of monoclonal antibody to CCNH on HeLa cell. [antibody concentration 10 ug/ml]
  • IHC - CCNH / Cyclin H Antibody (clone 1B8) ALS14322
    Anti-CCNH / Cyclin H antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P51946
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1B8
Calculated MW 38kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 902
Other Names Cyclin-H, MO15-associated protein, p34, p37, CCNH
Target/Specificity Human Cyclin H
Reconstitution & Storage Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
PrecautionsCCNH / Cyclin H Antibody (clone 1B8) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCNH
Function Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

References

Maekelae T.P.,et al.Nature 371:254-257(1994).
Fisher R.P.,et al.Cell 78:713-724(1994).
Ebert L.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
Shiekhattar R.,et al.Nature 374:283-287(1995).
Kershnar E.,et al.J. Biol. Chem. 273:34444-34453(1998).

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$ 450.00
Cat# ALS14322
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