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CACNA2D2 Antibody (clone 3A4)

Mouse Monoclonal Antibody

     
  • IHC - CACNA2D2 Antibody (clone 3A4) ALS14329
    Anti-CACNA2D2 antibody IHC of human kidney, tubules.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9NY47
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3A4
Calculated MW 130kDa
Dilution IHC-P (5 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 9254
Other Names Voltage-dependent calcium channel subunit alpha-2/delta-2, Voltage-gated calcium channel subunit alpha-2/delta-2, Voltage-dependent calcium channel subunit alpha-2-2, Voltage-dependent calcium channel subunit delta-2, CACNA2D2, KIAA0558
Target/Specificity Human CACNA2D2
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsCACNA2D2 Antibody (clone 3A4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CACNA2D2
Synonyms KIAA0558
Function The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.
Cellular Location Membrane; Single-pass type I membrane protein. Note=Colocalizes with CACNA1A in lipid raft fractions.
Tissue Location Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain.
Research Areas
Citations (0)

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Background

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.

References

Klugbauer N.,et al.J. Neurosci. 19:684-691(1999).
Gao B.,et al.J. Biol. Chem. 275:12237-12242(2000).
Hobom M.,et al.Eur. J. Neurosci. 12:1217-1226(2000).
Nagase T.,et al.DNA Res. 5:31-39(1998).
Muzny D.M.,et al.Nature 440:1194-1198(2006).

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$ 450.00
Cat# ALS14329
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