|Application ||WB, IHC-P, E|
|Dilution||IHC-P (5 µg/ml), WB (1:500-1:1000),|
|Other Names||Voltage-dependent calcium channel subunit alpha-2/delta-2, Voltage-gated calcium channel subunit alpha-2/delta-2, Voltage-dependent calcium channel subunit alpha-2-2, Voltage-dependent calcium channel subunit delta-2, CACNA2D2, KIAA0558|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||CACNA2D2 Antibody (clone 3A4) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.|
|Cellular Location||Membrane; Single-pass type I membrane protein. Note=Colocalizes with CACNA1A in lipid raft fractions.|
|Tissue Location||Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain.|
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Provided below are standard protocols that you may find useful for product applications.
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.
Klugbauer N.,et al.J. Neurosci. 19:684-691(1999).
Gao B.,et al.J. Biol. Chem. 275:12237-12242(2000).
Hobom M.,et al.Eur. J. Neurosci. 12:1217-1226(2000).
Nagase T.,et al.DNA Res. 5:31-39(1998).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
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