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OLIG2 Antibody (clone 3C9)

Mouse Monoclonal Antibody

     
  • IHC - OLIG2 Antibody (clone 3C9) ALS14330
    Anti-OLIG2 antibody IHC of human brain, oligodendroglia.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q13516
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3C9
Calculated MW 32kDa
Dilution IHC-P (5 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 10215
Other Names Oligodendrocyte transcription factor 2, Oligo2, Class B basic helix-loop-helix protein 1, bHLHb1, Class E basic helix-loop-helix protein 19, bHLHe19, Protein kinase C-binding protein 2, Protein kinase C-binding protein RACK17, OLIG2, BHLHB1, BHLHE19, PRKCBP2, RACK17
Target/Specificity Human Olig2
Reconstitution & Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsOLIG2 Antibody (clone 3C9) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name OLIG2
Synonyms BHLHB1, BHLHE19, PRKCBP2, RACK17
Function Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}. Cytoplasm. Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2
Tissue Location Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
Research Areas
Citations (0)

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Background

Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity).

References

Kuroda S.,et al.Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
Wang J.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:3497-3502(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Marie Y.,et al.Lancet 358:298-300(2001).
Lu Q.R.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:10851-10856(2001).

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$ 450.00
Cat# ALS14330
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