|Application ||WB, IHC-P, E|
|Dilution||IHC-P (5 µg/ml), WB (1:500-1:1000),|
|Other Names||B-cell lymphoma/leukemia 11A, BCL-11A, B-cell CLL/lymphoma 11A, COUP-TF-interacting protein 1, Ecotropic viral integration site 9 protein homolog, EVI-9, Zinc finger protein 856, BCL11A, CTIP1, EVI9, KIAA1809, ZNF856|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||BCL11A Antibody (clone 3D9) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CTIP1, EVI9, KIAA1809, ZNF856|
|Function||Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex (By similarity). Repressor of fetal hemoglobin (HbF) level (PubMed:26375765). Involved in brain development (PubMed:27453576). Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. Essential factor in lymphopoiesis required for B- cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (By similarity).|
|Cellular Location||Cytoplasm. Nucleus. Note=Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles (By similarity). Isoform 3: Cytoplasm. Nucleus. Note=Predominantly localized in the cytoplasm in the absence of interaction with isoform 1 and isoform 2. In presence of isoform 1 or isoform 2, translocates from the cytoplasm into nuclear paraspeckles|
|Tissue Location||Expressed at high levels in brain, spleen thymus, bone marrow and testis. Expressed in CD34-positive myeloid precursor cells, B-cells, monocytes and megakaryocytes. Expression is tightly regulated during B-cell development|
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Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (By similarity).
Saiki Y.,et al.Genomics 70:387-391(2000).
Satterwhite E.,et al.Blood 98:3413-3420(2001).
Suriyapperuma S.P.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 8:85-95(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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