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HSPA9 / Mortalin / GRP75 Antibody (aa630-679)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | P38646 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 74kDa |
| Dilution | ELISA (1:5000), IF (1:100-1:500), IHC-P (5 µg/ml), WB (1:500-1:1000) , |
| Gene ID | 3313 |
|---|---|
| Other Names | Stress-70 protein, mitochondrial, 75 kDa glucose-regulated protein, GRP-75, Heat shock 70 kDa protein 9, Mortalin, MOT, Peptide-binding protein 74, PBP74, HSPA9, GRP75, HSPA9B, mt-HSP70 |
| Target/Specificity | GRP75 Antibody detects endogenous levels of total GRP75 protein. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | HSPA9 / Mortalin / GRP75 Antibody (aa630-679) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HSPA9 (HGNC:5244) |
|---|---|
| Synonyms | GRP75, HSPA9B, mt-HSP70 |
| Function | Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). May play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). |
| Cellular Location | Mitochondrion. Nucleus, nucleolus. Cytoplasm |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone.
References
Domanico S.Z.,et al.Mol. Cell. Biol. 13:3598-3610(1993).
Bhattacharyya T.,et al.J. Biol. Chem. 270:1705-1710(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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