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SCHAD / HADHSC Antibody (clone 4B5)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E, IP |
|---|---|
| Primary Accession | Q16836 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 4B5 |
| Calculated MW | 34kDa |
| Dilution | IF (10 µg/ml), IHC-P (5 µg/ml), WB (1:500-1:1000) |
| Gene ID | 3033 |
|---|---|
| Other Names | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial, HCDH, 1.1.1.35, Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase, Short-chain 3-hydroxyacyl-CoA dehydrogenase, HADH, HAD, HADHSC, SCHAD |
| Target/Specificity | Human HADH |
| Reconstitution & Storage | Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles. |
| Precautions | SCHAD / HADHSC Antibody (clone 4B5) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HADH |
|---|---|
| Function | Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939, PubMed:16725361). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). |
| Cellular Location | Mitochondrion matrix |
| Tissue Location | Expressed in liver, kidney, pancreas, heart and skeletal muscle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA.
References
Vredendaal P.J.C.M.,et al.Biochem. Biophys. Res. Commun. 223:718-723(1996).
Shi Y.,et al.Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
O'Brien L.K.,et al.Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Choudhary C.,et al.Science 325:834-840(2009).
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