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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   AXL Antibody (clone 7E10)   

AXL Antibody (clone 7E10)

Mouse Monoclonal Antibody

     
  • IF - AXL Antibody (clone 7E10) ALS14407
    Confocal immunofluorescence of methanol-fixed HEK293 cells transfected with AXL-hIgGFc using AXL...
  • IHC - AXL Antibody (clone 7E10) ALS14407
    Anti-AXL antibody IHC of human prostate.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P30530
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 7E10
Calculated MW 98kDa
Dilution IF (1:200-1:1000), IHC-P (1:200), WB (1:500-1:2000)
Additional Information
Gene ID 558
Other Names Tyrosine-protein kinase receptor UFO, 2.7.10.1, AXL oncogene, AXL, UFO
Target/Specificity Human AXL
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsAXL Antibody (clone 7E10) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AXL
Synonyms UFO
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.
Volume 50 µl
Research Areas
Citations (0)

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Background

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor.

References

Partanen J.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:8913-8917(1990).
O'Bryan J.P.,et al.Mol. Cell. Biol. 11:5016-5031(1991).
Janssen J.W.G.,et al.Oncogene 6:2113-2120(1991).
Grimwood J.,et al.Nature 428:529-535(2004).
Lee S.-T.,et al.Oncogene 8:3403-3410(1993).

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$ 395.00
Cat# ALS14407
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