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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ERBB2IP / Erbin Antibody (C-Terminus)   

ERBB2IP / Erbin Antibody (C-Terminus)

Goat Polyclonal Antibody

  • IHC - ERBB2IP / Erbin Antibody (C-Terminus) ALS14409
    Anti-ERBB2IP / ERBIN antibody IHC of human colon, epithelium.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96RT1
Reactivity Human, Monkey, Horse
Host Goat
Clonality Polyclonal
Calculated MW 158kDa
Dilution ELISA (1:32000), IHC-P (3.75 µg/ml),
Additional Information
Gene ID 55914
Other Names Protein LAP2, Densin-180-like protein, Erbb2-interacting protein, Erbin, ERBB2IP, ERBIN, KIAA1225, LAP2
Target/Specificity Human ERBB2IP / ERBIN.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsERBB2IP / Erbin Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ERBIN, KIAA1225, LAP2
Function Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728).
Cellular Location Cell junction, hemidesmosome Nucleus membrane. Basolateral cell membrane. Note=Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity).
Tissue Location Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine
Research Areas
Citations (0)

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Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state.


Borg J.-P.,et al.Nat. Cell Biol. 2:407-414(2000).
Favre B.,et al.J. Biol. Chem. 276:32427-32436(2001).
Nagase T.,et al.DNA Res. 6:337-345(1999).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS14409
(40 western blots)
Availability: 5 days
Bulk Size
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