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ERP44 Antibody (clone 3C7)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E, IP |
|---|---|
| Primary Accession | Q9BS26 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 3C7 |
| Calculated MW | 47kDa |
| Dilution | IHC-P (3-5 µg/ml), WB (1:500-1:1000), |
| Gene ID | 23071 |
|---|---|
| Other Names | Endoplasmic reticulum resident protein 44, ER protein 44, ERp44, Thioredoxin domain-containing protein 4, ERP44, KIAA0573, TXNDC4 |
| Target/Specificity | Human TXNDC4 |
| Reconstitution & Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | ERP44 Antibody (clone 3C7) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ERP44 |
|---|---|
| Synonyms | KIAA0573, TXNDC4 |
| Function | Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif (PubMed:11847130, PubMed:14517240). Inhibits the calcium channel activity of ITPR1 (PubMed:15652484). May have a role in the control of oxidative protein folding in the endoplasmic reticulum (PubMed:11847130, PubMed:29858230, PubMed:14517240). Required to retain ERO1A and ERO1B in the endoplasmic reticulum (PubMed:11847130, PubMed:29858230). |
| Cellular Location | Endoplasmic reticulum lumen |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum.
References
Anelli T.,et al.EMBO J. 21:835-844(2002).
Nagase T.,et al.DNA Res. 5:31-39(1998).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
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