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NOX2 / gp91phox Antibody (clone 48)

Mouse Monoclonal Antibody

     
  • IHC - NOX2 / gp91phox Antibody (clone 48) ALS14436
    Anti-NOX2 antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P04839
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 48
Calculated MW 65kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 1536
Other Names Cytochrome b-245 heavy chain, 1.-.-.-, CGD91-phox, Cytochrome b(558) subunit beta, Cytochrome b558 subunit beta, Heme-binding membrane glycoprotein gp91phox, NADPH oxidase 2, Neutrophil cytochrome b 91 kDa polypeptide, Superoxide-generating NADPH oxidase heavy chain subunit, gp91-1, gp91-phox, p22 phagocyte B-cytochrome, CYBB, NOX2
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsNOX2 / gp91phox Antibody (clone 48) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYBB
Synonyms NOX2
Function Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Detected in neutrophils (at protein level).
Volume 50 µl
Research Areas
Citations (0)

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Background

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.

References

Royer-Pokora B.,et al.Nature 322:32-38(1986).
Jirapongsananuruk O.,et al.Clin. Immunol. 104:73-76(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Dinauer M.C.,et al.Nature 327:717-720(1987).

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$ 395.00
Cat# ALS14436
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