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EP / DBI Antibody (clone 20B10)

Mouse Monoclonal Antibody

     
  • IP - EP / DBI Antibody (clone 20B10) ALS14441
    0
  • IHC - EP / DBI Antibody (clone 20B10) ALS14441
    Anti-DBI antibody IHC of human small intestine.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E, IP
Primary Accession P07108
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 20B10
Calculated MW 10kDa
Dilution IHC-P (1:200)
Additional Information
Gene ID 1622
Other Names Acyl-CoA-binding protein, ACBP, Diazepam-binding inhibitor, DBI, Endozepine, EP, DBI
Reconstitution & Storage Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
PrecautionsEP / DBI Antibody (clone 20B10) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DBI
Function Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
Cellular Location Endoplasmic reticulum. Golgi apparatus. Note=Golgi localization is dependent on ligand binding (PubMed:17953517)
Tissue Location Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart.
Volume 50 µl
Research Areas
Citations (0)

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Background

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.

References

Gray P.W.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:7547-7551(1986).
Webb N.R.,et al.DNA 6:71-79(1987).
Nitz I.,et al.Int. J. Biochem. Cell Biol. 37:2395-2405(2005).
Ludewig A.H.,et al.IUBMB Life 63:547-552(2011).
Nitz I.,et al.J. Cell. Mol. Med. 15:909-927(2011).

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$ 395.00
Cat# ALS14441
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