MAP4K1 / HPK1 Antibody (clone 2A1)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IP |
---|---|
Primary Accession | Q92918 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 2A1 |
Calculated MW | 91kDa |
Dilution | IHC-P (1:200), WB (1:5000), |
Gene ID | 11184 |
---|---|
Other Names | Mitogen-activated protein kinase kinase kinase kinase 1, 2.7.11.1, Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, MEKKK 1, MAP4K1, HPK1 |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles. |
Precautions | MAP4K1 / HPK1 Antibody (clone 2A1) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MAP4K1 |
---|---|
Synonyms | HPK1 |
Function | Serine/threonine-protein kinase, which may play a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:8824585, PubMed:24362026). Able to autophosphorylate (PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). |
Tissue Location | Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine |
Volume | Array |
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Background
Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.
References
Hu M.C.-T.,et al.Genes Dev. 10:2251-2264(1996).
Grimwood J.,et al.Nature 428:529-535(2004).
Oppermann F.S.,et al.Mol. Cell. Proteomics 8:1751-1764(2009).
Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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