PTPN6 / SHP1 Antibody (clone 14D5)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | P29350 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 14D5 |
Calculated MW | 68kDa |
Dilution | IHC-P (1:200), WB (1:2000), |
Gene ID | 5777 |
---|---|
Other Names | Tyrosine-protein phosphatase non-receptor type 6, 3.1.3.48, Hematopoietic cell protein-tyrosine phosphatase, Protein-tyrosine phosphatase 1C, PTP-1C, Protein-tyrosine phosphatase SHP-1, SH-PTP1, PTPN6, HCP, PTP1C |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles. |
Precautions | PTPN6 / SHP1 Antibody (clone 14D5) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PTPN6 |
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Synonyms | HCP, PTP1C |
Function | Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. |
Cellular Location | Cytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity) Shuttles between the cytoplasm and nucleus via its association with PDPK1. |
Tissue Location | Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells |
Volume | 50 µl |
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Background
Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
References
Yi T.,et al.Mol. Cell. Biol. 12:836-846(1992).
Shen S.H.,et al.Nature 352:736-739(1991).
Shen S.H.,et al.Nature 353:868-868(1991).
Plutzky J.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:1123-1127(1992).
Banville D.,et al.Genomics 27:165-173(1995).
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