|Application ||WB, IHC-P, E|
|Dilution||IHC-P (1:200), WB (1:2000),|
|Other Names||Tyrosine-protein phosphatase non-receptor type 6, 22.214.171.124, Hematopoietic cell protein-tyrosine phosphatase, Protein-tyrosine phosphatase 1C, PTP-1C, Protein-tyrosine phosphatase SHP-1, SH-PTP1, PTPN6, HCP, PTP1C|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.|
|Precautions||PTPN6 / SHP1 Antibody (clone 14D5) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.|
|Cellular Location||Cytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1.|
|Tissue Location||Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells|
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Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
Yi T.,et al.Mol. Cell. Biol. 12:836-846(1992).
Shen S.H.,et al.Nature 352:736-739(1991).
Shen S.H.,et al.Nature 353:868-868(1991).
Plutzky J.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:1123-1127(1992).
Banville D.,et al.Genomics 27:165-173(1995).
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