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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CHGA / Chromogranin A Antibody   

CHGA / Chromogranin A Antibody

Mouse Monoclonal Antibody

     
  • WB - CHGA / Chromogranin A Antibody ALS14449
    0
  • IHC - CHGA / Chromogranin A Antibody ALS14449
    Anti-CHGA / Chromogranin A antibody IHC of human adrenal.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P10645
Reactivity Human
Host Mouse
Clonality Monoclonal
Calculated MW 51kDa
Dilution IHC-P (1:200), WB (1:2000),
Additional Information
Gene ID 1113
Other Names Chromogranin-A, CgA, Pituitary secretory protein I, SP-I, Vasostatin-1, Vasostatin I, Vasostatin-2, Vasostatin II, EA-92, ES-43, Pancreastatin, SS-18, WA-8, WE-14, LF-19, AL-11, GV-19, GR-44, ER-37, CHGA
Reconstitution & Storage Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
PrecautionsCHGA / Chromogranin A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CHGA
Function Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas. Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
Cellular Location Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle membrane. Secreted. Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions.
Tissue Location GE-25 is found in the brain.
Volume 50 µl
Research Areas
Citations (0)

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Background

Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.

References

Konecki D.S.,et al.J. Biol. Chem. 262:17026-17030(1987).
Helman L.J.,et al.J. Biol. Chem. 263:11559-11563(1988).
Mouland A.J.,et al.J. Biol. Chem. 269:6918-6926(1994).
Mouland A.J.,et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS14449
Size:
Quantity:
(40 western blots)
Availability: 5 days
Bulk Size
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