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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CBR / CBR1 Antibody (clone AT4E12)   

CBR / CBR1 Antibody (clone AT4E12)

Mouse Monoclonal Antibody

     
  • WB - CBR / CBR1 Antibody (clone AT4E12) ALS14452
    Cell lysates (40 ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with...
  • IHC - CBR / CBR1 Antibody (clone AT4E12) ALS14452
    Anti-CBR1 antibody IHC of human small intestine.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P16152
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Clone Names AT4E12
Calculated MW 30kDa
Dilution IHC-P (10 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 873
Other Names Carbonyl reductase [NADPH] 1, 1.1.1.184, 15-hydroxyprostaglandin dehydrogenase [NADP(+)], 1.1.1.197, NADPH-dependent carbonyl reductase 1, Prostaglandin 9-ketoreductase, Prostaglandin-E(2) 9-reductase, 1.1.1.189, CBR1, CBR, CRN
Target/Specificity Human CBR1
Reconstitution & Storage Can be stored at 4°C. For long term storage, aliquot and store at -20°C. Avoid repeated freezing and thawing cycles.
PrecautionsCBR / CBR1 Antibody (clone AT4E12) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBR1
Synonyms CBR, CRN, SDR21C1
Function NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
Cellular Location Cytoplasm.
Volume 50 µl
Research Areas
Citations (0)

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Background

NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.

References

Wermuth B.,et al.J. Biol. Chem. 263:16185-16188(1988).
Forrest G.L.,et al.Biochim. Biophys. Acta 1048:149-155(1990).
Forrest G.L.,et al.Mol. Pharmacol. 40:502-507(1991).
Watanabe K.,et al.Genomics 52:95-100(1998).
Terada T.,et al.Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS14452
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